Mesodermal development in mouse embryos mutant for fibronectin
نویسندگان
چکیده
منابع مشابه
Facial development in the mouse; a comparison between normal and mutant (amputated) mouse embryos.
This work extends previous investigations into cell interactions involved in specific morphogenetic events during the development of normal and mutant (amputated) mouse embryos. In the mutant mesenchyme, cells tend to clump together and form far more extensive areas of cell contact than are found in normal mesenchyme. This is confirmed for mutant facial mesenchyme. Facial outgrowth in the mutan...
متن کاملDefects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin.
To examine the role of fibronectin in vivo, we have generated mice in which the fibronectin gene is inactivated. Heterozygotes have one half normal levels of plasma fibronectin, yet appear normal. When homozygous, the mutant allele causes early embryonic lethality, proving that fibronectin is required for embryogenesis. However, homozygous mutant embryos implant and initiate gastrulation normal...
متن کاملIntegrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies
Vascular development and maturation are dependent on the interactions of endothelial cell integrins with surrounding extracellular matrix. Previous investigations of the primacy of certain integrins in vascular development have not addressed whether this could also be a secondary effect due to poor embryonic nutrition. Here, we show that the 5 integrin subunit and fibronectin have critical role...
متن کاملCentral Roles of a5b1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies
Vascular development and maturation are dependent on the interactions of endothelial cell integrins with surrounding extracellular matrix. Previous investigations of the primacy of certain integrins in vascular development have not addressed whether this could also be a secondary effect due to poor embryonic nutrition. Here, we show that the a5 integrin subunit and fibronectin have critical rol...
متن کاملCentral roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies.
Vascular development and maturation are dependent on the interactions of endothelial cell integrins with surrounding extracellular matrix. Previous investigations of the primacy of certain integrins in vascular development have not addressed whether this could also be a secondary effect due to poor embryonic nutrition. Here, we show that the alpha5 integrin subunit and fibronectin have critical...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 1996
ISSN: 1058-8388,1097-0177
DOI: 10.1002/(sici)1097-0177(199610)207:2<145::aid-aja3>3.0.co;2-h